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Protein interaction antibody pairs are sets of antibodies that are known to be capable of detecting specific protein - protein interactions; they can be used together in an immunoassay.
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This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
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HMB45 + MART-1 + Tyrosinase is a first-order pan melanoma screener. HMB45 labels the majority of melanomas. MART-1 is specific to melanocytic lesions. Tyrosinase labels a high percentage of desmoplastic melanomas.
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CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
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